The chick dermis is known to control the formation of feathers and interfeathery skin in a hexagonal pattern. Rings of C-Deltaexpressing fibroblasts precede and delimit the forming feather primordia. C-Delta-1 is uniformly expressed in the dermis of the scaleless mutant, which is almost entirely devoid of feathers. Feather development is inhibited by overexpression of C-Delta-1 in wild type dermis using a retroviral construct.
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